Coconut Oil, Ketones and Alzheimer's

Tuesday, August 17, 2010

Bad news for Eli Lilly Drug Trial/ More thought about beta-amyloid and infection

The Eli Lilly drug that has been in phase III trials has been stopped due to increased risk of skin cancer and, even worse, an acceleration of deterioration of AD compared to the placebo, the opposite of what was hoped for. This is yet another sad turn of events. Steve was in this study but we stopped in the winter due to several side effects; I believe he was on the actual drug for only about a month at that point. His hair started to grow out a very light gold color (one of the known effects that didn't bother us)and when we stopped it, the darker hair grew in again. He had a half inch white stripe work its way out to the tips of his hair! I no longer have any regrets that we pulled him out of the study.

I believe the worsening of AD in people who were on this drug supports infection as at least one important cause of Alzheimer's disease. One group has found that beta-amyloid kills microbes; they tested a number of bacteria, all of which were killed by beta-amyloid, and this group is now looking at viruses, such as herpes simplex, and other microbes (Soscia "The Alzheimer’s Disease-Associated Amyloid b-Protein Isan Antimicrobial Peptide" PLOS March 2010,Volume 5, Issue 3, e9505: www.plosone.org). If a drug is used to suppress the production of beta-amyloid and it normally is part of the brain's defense against infection, then infection could spread more readily and potentially cause more extensive damage to brain tissue. Beta-amyloid may be more prevalent in people with AD because they have chronic, recurrent infections that are provoking this response. So the increase in amyloid may be the aftermath, no the cause of, the process that does cause AD.

Drs. Ruth Itzhaki and Mark Wozniak in the UK have done extensive work looking at the herpes simplex virus as a cause of AD (they have numerous papers on this from 2005 through 2009.) This virus causes fever blisters, can cause shingles (along with the chickenpox virus, a close relative), and also genital herpes. Herpes simplex lives within nerves and the nerves to the face around the mouth orignate deep in the brain. Most people carry this and other viruses by the time they reach old age, but they have found that people who are ApoE4+ are particularly likely to suffer recurrent episodes of fever blisters. these researchers have found this virus within about 90% of the beta-amyloid plaques in the autopsied brains they have looked at, which strongly suggests that beta-amyloid is there to defend the brain against it. They have also found in animals that the herpes virus increases production of beta-amyloid and also induces AD-like tau phosphorylation (production of tangles). They want to study whether suppression of herpes virus with anti-viral medication would be beneficial to people with AD, but have had trouble getting funding for this.

Acyclovir, for example, is taken daily orally by many people to suppress the genital variety of herpes simplex, including woman who are pregnant, to try to prevent spread of the nfection to the newborn. Perhaps such a treatment could decrease the number and severity of outbreaks in the brain as well. Lysine (available OTC) is used to suppress herpes infections and the lauric acid (C:12) and capric acid (C:10)found in coconut oil kill herpes family of viruses by dissolving the lipid capsule around the virus.

It could also be that, even though beta-amyloid is there to fight infection, it causes some of the damage as well; if you think about it, whenever there is inflammation, part of the body's defensive reaction to infection, there can be damage/scarring to the nearby tissue from the inflammation. The infectious agent is the cause of the whole process, but the body's defenses can also cause some collateral damage, in order to preserve the whole person.

I hope work by Itzhaki and others studying infection will be taken more seriously so that they can get the funding they need.

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7 Comments:

  • Hello Dr. Newport!

    "...and the lauric acid (C:12) and capric acid (C:10)found in coconut oil kill herpes family of viruses by dissolving the lipid capsule around the virus."
    - Yes! Medium chain fatty acids (MCFA) like capric and lauric acids can kill lipid-coated viruses like the herpes family of viruses, including HIV (AIDS), SARS and many more. Just my two cents.

    Cheers,
    CoconutOilGuy
    www.coconut-oil-central.com
    Your Drugstore in a Bottle

    By Blogger Frederick, At August 18, 2010 at 5:48 PM  

  • Infection might cause an increase of TNF-alpha, which is what the arthritis drug Enbrel blocks. This would tie into the reported benefits to AD patients of introducing Enbrel into the CSF. But it also points to a better strategy of addressing the cause of the increased levels of TNF-alpha: infection. There is some intriguing evidence from a study in Greece that found eliminating a Helicobacter pylori infection of the stomach halted AD progression. Other infections of the teeth and gums might also contribute.

    By Blogger PC, At October 7, 2010 at 9:06 AM  

  • Please refer to Keep Hope Alive dot org for much more regarding coconut oil and antiretrovitals

    By Blogger herbalYODA, At October 11, 2010 at 9:09 AM  

  • Hello Dr. Newport.
    Following you and your husband from a distance, hoping with you.

    Have you looked in to the research on turmeric and AD?

    I can´t find adverse effect, and it´s easy to make capsules and try this spice, (or going steady in the more Asian food direction. There is some interesting results showing up on the effect.


    Take a look in pubmed, and search for: turmeric alzheimers

    Here is one example.
    http://www.ncbi.nlm.nih.gov/pubmed/20622013

    All the best

    By Anonymous Anonymous, At November 2, 2010 at 4:25 PM  

  • Hello Dr. Newport,
    My daughter is 18 years old with Down Syndrome and about two years ago she regressed. The doctor said its depression but could never really pinpoint a reason. When I asked about Alzheimers he said she's just too young for that.

    However, the amyloid plaques found in Alzheimers are strongly linked to individuals with Downs Syndrome(DS) and many people with DS develop Alzheimers very early in life. It has been recorded that signs of Alzheimers start in people with DS as early as 30 but many other parents like me who child has regressed in their early child hood and teens believe it can begin much much younger than age 30. Please visit the website of Teresa Cody and the Changing Minds foundation regarding memory, cognitive, natural treaments and research.

    I can't wait to start my daughter on coconut oil today as well as the rest of my family!

    Here are some links worth reviewing:
    http://www.sciencedaily.com/releases/2010/01/100115182639.htm

    http://changingmindsfoundation.org/

    Thank you for working to make the Coconut Oil and Ketones information public!

    By Blogger Char, At December 3, 2010 at 12:50 PM  

  • Dr. Newport,

    One more thing; You mention Curcumin in your youtube video.

    Another intesting product is Longvida Curcumin. It's able to cross the brain barrier and people have seen very good results with it as well.

    Read more about it here: http://www.longvida.com/index.php

    By Blogger Char, At December 3, 2010 at 12:59 PM  

  • You may want to avoid using power blenders (magic bullet, etc.) in mixing some nutrients. Some nutritionists and marketers of whey proteins that are processed at very low temperatures, to preserve the components of raw milk, warn that some of these items can be damaged by fast blending, and should be shaken by hand or stirred. I don't know if MCFA would be subject to such damage. Better safe than sorry.

    By Anonymous Anonymous, At December 21, 2010 at 1:01 AM  

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