Coconut Oil, Ketones and Alzheimer's

Friday, February 17, 2017

BIOCHEMISTRY 101: WHAT ARE KETONES AND WHERE DO THEY COME FROM?

                If you are new to the world of ketones and ketone salts, you might have a very basic question, what are ketones and where they come from?  So we will start with a lesson from biochemistry 101 that I will try to make as simple as possible. The word “ketone” comes from the German word “keton” meaning acetone, which is your basic fingernail polish remover! This is the very same acetone that is one of the three basic ketone bodies produced in our bodies (I will talk more about that later).
“Atoms” are the basic particles of matter. The basic atoms in living matter are oxygen, hydrogen and carbon.  Atoms are connected to each other by “bonds” that are sort of like magnetic attractions.  When two or more atoms are connected, they are called “molecules”. Glucose (sugar), fats and ketones are made of different combinations of oxygen, hydrogen and carbon. The carbon atoms line up in a chain and the hydrogen and oxygen atoms attach to the carbon atoms.  The positions of the atoms in a molecule determine what it does in the body. 
Glucose starts with a chain of six carbons with hydrogens and oxygens attached to them and is the main fuel for the cells in our body when we are on a higher carbohydrate diet.  Betahydroxybutyrate is one of the three ketones made in the body and starts with a chain of four carbons with hydrogens and oxygens attached. There are two forms of betahydroxybutyrate that have a different shape – the simplest way to think of them is as mirror images. D-betahydroxybutyrate is found mainly in the bloodstream and L-betahydroxybutyrate is found mainly in mitochondria where energy, called ATP, is produced in our cells. There are two other ketones, one called acetoacetate and the other called acetone (finger nail polish remover!), which evaporates easily and is mostly exhaled.  Acetone accounts for the fruity breath people may have when they are in ketosis (meaning when blood ketone levels are elevated). Acetoacetate converts easily to betahydroxybutyrate and vice versa. Acetoacetate also breaks down to acetone.
Endogenous ketones are ketones that originate inside of our bodies. The most common way that we experience ketosis is when we do not eat for 10 or 12 hours overnight; we will often be in mild ketosis in the morning until we eat something with carbohydrates (sugar) in it. Ketosis becomes much more pronounced over days to weeks in people who are fasting intentionally, starving, or on a high-fat low-carbohydrate diet.  In this situation, we begin breaking down fat into fatty acids after the glucose that is stored in our body is used up, usually within 36 to 48 hours. These relatively large fatty acids do not cross very well into the brain, however they are broken down in the liver to ketones. The cool thing about ketones is that they do cross the blood brain barrier and provide fuel to the cells in our brain as well as in our other organs (except in the liver where they are made). Both glucose and ketones enter the same chemical pathway that leads to producing ATP, however ketones enter this pathway several steps downstream from where glucose enters. Because of this, ketones can serve as an alternative fuel to the brain and other organs when there is a problem using glucose for fuel.
Exogenous ketones originate from outside of the body. Pruvit ketone salts, Keto//OS and KetoMax, are natural exogenous ketones and are the first products to be widely marketed to the public that contain the actual ketone betahydroxybutyrate!

Coming soon: How Do Ketones Work?

Sunday, January 8, 2017

KETONE SALTS EXPLAINED

Ketone salts AKA Keto//OS were developed and tested at the University of South Florida in the labs of Dr.Dominic D’Agostino and have just become widely available in 2016 through network marketing by Pruvit.
Ketone salts are carefully formulated and contain the actual ketone betahydroxybutyrate bound to sodium, calcium and magnesium and can increase ketone levels much higher than coconut or MCT oil and could bring about even more improvement. Using ketone salts could be part of the overall strategy to raise ketones, keeping coconut and MCT oil as the foundation.

Ketone salts are now widely used by people with a variety of conditions who are reporting positive responses, including brain fog, memory impairment, sleep problems, low energy, and conditions  caused by inflammation (ketones are anti-inflammatory in addition to providing alternative fuel to the brain and other organs).  Many people have reported substantial fat loss, especially when combined with a low carb diet and without hunger (ketones can suppress appetite and encourage fat loss by reducing glucose and insulin levels and stimulating fat breakdown).  World class athletes and body builders are using ketone salts to enhance physical performance.

A healthy person could take a full serving of Pruvit KetoOS or KetoMax right away. For elderly people or those with chronic medical conditions I recommend getting doctor's approval, so that electrolytes can be monitored and I suggest starting slowly - 1 or 2 teaspoons once or twice a day and increasing gradually over a week or two as tolerated to 1/2 to 1 serving daily, or more as tolerated.  Also very important - the person taking the salts needs to be able to drink plenty of fluids to avoid a dehydrating effect of raising ketones.

The KetoOS 2.1 orange dream flavor is the ketone betahydroxybutyrate PLUS MCT oil powder with mild oragne flavor and stevia.  Works well in hot or cold drink - tea (cold or hot), water or sparkling water.  I know someone who doesn't like it as a drink but puts it into Jello!!

The KetoOS 3.0 chocolate swirl has a light chocolate flavor and contains the ketone betahydroxybutyrate but NO MCT.  It does contain certain amino acids that help maintain muscle mass.

The KetoMax is Hawaiian punch flavor and is probably the best at elevating ketone levels the highest. Can be used in cold or hot drinks.  It is the more bio-available form of betahydroxybutyrate called the D-form.  Also has no MCT.  KetoMax will be coming out in a “hot cocoa” flavor soon.

KetoKreme is a combination of coconut and MCT powder (no betahydroxybutyrate) with stevia and cinnamon that you can put into a warm drink like coffee or tea.  I use this one myself in the morning in coffee and love it.


The most economical way to buy the ketone salts is a 30 day serving supply in a can which comes with a one serving scoop.  One scoop contains about 8 level teaspoons of the ketone salt powder, so if someone starts with one or two teaspoons as their serving the can could potentially last quite a bit longer than a month.  For more information you can link through my website www.coconutketones.com OR www.marynewport.pruvitnow.com

Saturday, August 10, 2013

The Eating Academy - Good articles on ketosis and many other topics by Dr. Peter Attia


Here is a link to a blog by Peter Attia, MD on nutrition, stressing low carbohydrate diet with many very interesting articles on ketosis (see part I and Part II).

http://eatingacademy.com/start-here

Wednesday, August 7, 2013

Dr. Stephanie Seneff of MIT on Cholesterol, ApoE4, Statins, Beta Amyloid and Alzheimer's



Here is a link to a very thorough and highly researched article by Dr. Stephanie Seneff of MIT discussing the importance of fat and cholesterol, how they work in the brain, why statin use may be counterproductive for people at risk for and dealing with Alzheimer's, the function of beta amyloid and why a high fat diet may be beneficial.  I found this especially enlightening in its explanation of how cholesterol is packaged as it is transported throughout the body, and what it is packaged with in LDL particles, for example, may be a surprise.

http://coconutoil.com/the-clue-to-why-low-fat-diet-and-statins-may-cause-alzheimers/

Dr. Seneff has written many other similar articles of great interest to those concerned with cholesterol, statins, Alzheimer's, autism and other neurodegenerative diseases, many of which can be downloaded from her homepage.  http://people.csail.mit.edu/seneff/

Labels: , , , , , , ,

Tuesday, July 23, 2013

Fuel for Thought

Many people ask me to suggest a convenient way that does not involve cooking to provide coconut and MCT oil for their loved ones who are in assisted living, or are looking for a convenient way to take it at home, or carry along while travelling or just out and about.  One such product is called Fuel for Thought and is available directly from Cognate Nutritionals by way of  www.cognatenutritionals.com or by calling  (855) 453-8663.  The company is located in the USA in Connecticut.  In the first edition of my book, the working name of this product was Cocomul but is now called Fuel for Thought.

Steve and I have had the opportunity to try out Fuel for Thought and it is a delicious, creamy vanilla flavored liquid that is easiest taken as is but can also be mixed into other foods and liquids.  Fuel for Thought® has been scientifically designed to provide a high concentration of MCTs which are partly converted in the liver to ketones that act as alternative fuel for brain cells.  In this regard, it has been designed to support cognitive health.  The makers state this product contains NO cholesterol, gluten, transfats, soy, dairy, or fructose, is vegetarian and very low in sodium. 

The beauty of Fuel for Thought is that it is packaged in one ounce single-serving bottles that do not require refrigeration, and are  sold as a case containing 60 doses.  For someone in assisted living, rather than trying to provide food containing coconut oil or getting the staff to give the patient coconut oil, the loved one's physician could order that Fuel for Thought be provided to the patient at set times of day, with meals, for example.

The recommendation from the company is to take one bottle twice a day, beginning with a portion of the bottle initially and increasing as tolerated.  The product is designed such that the amount of ketones produced by taking one ounce is equal to three tablespoons of coconut oil but with only 100 calories, as opposed to about 360 calories from the equivalent amount of coconut oil.

The product is currently being studied in a clinical trial of Alzheimer's and coconut/MCT oil versus placebo at the Byrd Alzheimer's Institute at University of South Florida in Tampa.
It is comparable to my idea of mixing coconut oil and MCT oil to reach higher levels of ketones while retaining the many health benefits of coconut oil.  I am giving Steve this mixture several times a day to try to keep ketones available to his brain 24/7.  For that reason I am involved with the company as a scientific advisor.
 
The concept here is that MCT oil is partly converted in the liver to ketones which act in the brain as an alternative fuel to glucose. People who have insulin deficiency or insulin resistance have difficulty getting glucose, the usual primary fuel for the brain and other organs, into the cells and eventually they malfunction and diet. This product would be useful not only for people who suffer from Alzheimer’s, but also, Parkinson’s, ALS, multiple sclerosis, diabetes, Huntington’s, and most other conditions where there is insulin resistance or decreased glucose uptake into cells.

Labels: , , , , , , ,

TED x USF talk link

I have been having trouble getting by drafts to publish on my blog lately but now appear to be okay!

Here is a link to a TED talk I did in February at TEDxUSF in later February - 18 minutes long:

http://www.youtube.com/watch?v=Dvh3JhsrQ0w

Labels: , , , , , , ,

Tampa Bay Times Article - Byrd Alzheimer's Institute to study coconut oil in people with Alzheimer's!


Here is a link to the story:

http://www.tampabay.com/news/health/spring-hill-couple-inspires-research-into-coconut-oil-for-alzheimers/2124596

This story spawned a similar TV story on ABC Action News that aired in the Tampa Bay area.  I will post a link when I receive it.

Sorry I have not posted here much lately!  I have been more active on Facebook.  Just look up Mary Newport and ask to be friends.

The second edition of my book was released a couple of months ago.  There is a link to order from Amazon on my website www.coconutketones.com.



Labels: , , , , , , ,