There
is a tiny worm that may tell us a big story about ketones. Called Caenorhabditis elegans, or C. elegans for short, this is a
transparent free-living nematode (roundworm) less than 1/8 inch long (1 mm)
that moves like a snake. The worm lives only about 2 to 3 weeks and emits a
blue fluorescence when it dies. It is one
of the simplest organisms that has a nervous system, consisting of 302 neurons
(brain cells) and has been used extensively since 1963 in medical research. Every type of cell in this worm has been thoroughly
studied and its entire genome has been mapped out. C.elegans is a regular passenger on space
flights and on the space station and actually survived the space shuttle
Columbia disaster in 2003. It has been
used to study conditions like nicotine addiction, effects of zero gravity on
muscle atrophy, sleep and aging.
So,
what does this have to do with ketones? A
recent research study using C.elegans strongly suggests that ketones extend lifespan
and have anti-aging effects. As we age,
our cells deteriorate, often leading to chronic medical conditions and brain
diseases like Alzheimer’s and Parkinson’s. Dietary restriction of calories slows
the process of aging down and increases the lifespan of many organisms including
primates and C.elegans. Dietary restriction is known to increase ketone levels
and this could at least partly explain its effects on prolonging life. Researchers in the anti-aging field look for
substances that mimic dietary restriction and lead to longer lifespan and delay
the onset of diseases of aging. It turns
out that the ketone betahydroxybutyrate, found in ketone salts (marketed by the
Pruvit company), is one of those anti-aging substances. Medium-chain
triglycerides (MCT) found in coconut oil, palm kernel oil and MCT oil, partly
convert to betahydroxybutyrate as well.
In
2015, researchers at the University of South Florida published their study in
which they found that high levels of D-betahydroxybutyrate extended the
lifespan of C.elegans by 26% and that this effect was likely due, at least in
part, to suppressing certain enzymes involved in inflammation and damage from
reactive oxygen species. They then studied the effects of betahydroxybutyrate
on models of the worm that were engineered to represent Alzheimer’s disease and
Parkinson’s disease. They further found that
betahydroxybutyrate delayed the onset of signs of Alzheimer’s in the worm by
15% and also delayed the formation of clumps of the abnormal protein found in
Parkinson’s disease by 35%. The bottom line here is that
betahydroxybutyrate prolonged the lifespan and was found to protect brain cells
in the worm.
In
an article published in 2017, Dr. Richard L. Veech and his associates at the
National Institutes of Health further explain how these findings in C.elegans might
be translated to prolonging human lifespan and delaying effects of aging on the
brain. The likely ketone effects
involved include anti-inflammatory effects, reduction of damage from reactive
oxygen species, and reducing levels of glucose and insulin. My summary here is just a simple explanation
for the very technical, complicated biochemistry involved.
We
gigantic humans share many of the same chemical pathways as C. elegans,
including those studied in the University of South Florida experiments. Do ketones
have anti-aging effects? Based on the
latest information from studying this little worm, the answer to this question appears
to be yes!
References:
Edwards C, J Canfield, N Copes, et al.
D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging Vol. 6 No. 8 (2014):1-24.
Edwards C, N Copes, PC Bradshaw.
D-beta-hydroxybutyrate: an anti-aging ketone body. Oncotarget Vol. 6 No. 6 (2015): 3477-8.
Veech RL, PC Bradshaw, K Clarke, et al. Ketone
bodies mimic the life span extending properties of caloric restriction. IUBMB Life Vol. 69 No. 5 (2017):305-314.
Labels: AD, aging, Alzheimer's, anti-aging, betahydroxybutyrate, caloric restriction, coconut oil, inflammation, ketogenic diet, ketones, MCT oil, medium chain triglycerides
105 Comments:
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In the case of Mum, she was having persecurtory delusions, auditory hallucinations and negative symptoms that had lasted for at least Three years. All of these symptoms fit with a diagnosis of Dementia. Her story reflects a common case, in which a high-functioning young adult goes through a major decline in day-to-day skills. Although family and friends may feel this is a loss of the person they knew, the illness can be treated and a good outcome is possible as it all got better when we started using a herbal medicine for her through Aparajita.
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I had a sudden onset of cold sores and a new one was appearing each day. I was on primary immunosuppressant I noticed my body just can't fight the virus on its own. After five days of treatment and no success I suspected herpes I went for test and it was confirmed. God was my strength I met a doctor for treatment. He gave me Dr Utu's contact. I contacted him immediately, This medication was far amazing that within 24-48 hrs the blisters were crusting over. The swelling and redness was decreasing as well. I was on four weeks herpes medication which I completed before going for test. I went for herpes test and then again back to my doctor who confirmed me herpes negative it was really like a dream. What a relief! Feel Free to contact Dr Utu Email:- drutuherbalcure@gmail.com OR WhatsApp :- +2347032718477
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September 14, 2019 at 9:26 AM
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This was the same question that prompted me to read further a testimony I saw on a blog. I would like to tell a story - hoping it will be useful to others - of my struggles and achievements with Dementia. I was diagnosed a little over 4 years ago, No doctors I met have any treatment or even suggestions apart western medications. I even sought advice on Youtube, to no avail. After using the conventional approach to medication treatment without improvement. I am glad something happens fast. There have been suicides due to people not being able to continue on living with the endless memory challenges. It is horrible. I learned about Dr. charanjit herbal medicine that works effectively for me without any negative effects. I have returned back to my normal life and I hope that the symptoms do not return again, It really helped me! If you have Dementia kindly contact Dr. Charanjit for help and necessary solution (charantova@gmail.com)
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September 15, 2019 at 3:02 AM
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I had a sudden onset of cold sores and a new one was appearing each day. I was on primary immunosuppressant I noticed my body just can't fight the virus on its own. After five days of treatment and no success I suspected herpes I went for test and it was confirmed. God was my strength I met a doctor for treatment. He gave me Dr Utu's contact. I contacted him immediately, This medication was far amazing that within 24-48 hrs the blisters were crusting over. The swelling and redness was decreasing as well. I was on four weeks herpes medication which I completed before going for test. I went for herpes test and then again back to my doctor who confirmed me herpes negative it was really like a dream. What a relief! Feel Free to contact Dr Utu Email:- drutuherbalcure@gmail.com OR WhatsApp :- +2347032718477
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Using herbal natural remedy was what got me tested negative to HSV 2 after been diagnosed for years.I have spend so much funds on medications like acyclovir (Zovirax), Famciclovir (Famvir), and Valacyclovir (Valtrex). But it was all a waste of time and my symptoms got worst. To me It is very bad what Big pharma are doing, why keep making humans suffer greatly just to get profits annually for medications that doesn't work. I'm glad that herbal remedies is gaining so much awareness and many people are getting off medications and activating their entire body system with natural herbal remedies and they are become holistically healed totally. Quickly contact Dr Akhere herbal home now on his contact field on his website: http://drakhereherbalhome.wixsite.com/website or email him directly on drakhereherbalhome017@gmail.com
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